How your art is to be implemented into your game engine should be on your mind from the start. Study the ins and outs of the engine you’re using, if any, and connect with others more experienced than you. Ask, ask, ask, and don’t be afraid to contact other game developers to see how they’re accomplishing their project.
You may run into roadblocks in the form of assets not working in the way you expected them to, or garbled communication between team members. Don’t give up and persevere- bugs and unexpected issues are a natural part of game development whether you’re a one-man team or a part of a huge company. Never forget that you’re solving dozens if not hundreds or thousands of problems when developing a game!
